Chromodoris africana, or four-coloured nudibranch, is a species of colourful sea slug, a dorid nudibranch, a marine gastropod mollusc in the family Chromodorididae.
This species may grow to 75mm in total length. It is a smooth-bodied nudibranch, with a black ground colour, two white lines running down the notum, which has a white rim, and an orange margin. The gills and rhinophores are yellow to orange.
C. africana feeds on sponges. It is known to eat a species of the sponge genus Negombata.