The Rio Grande worm lizard (Amphisbaena pretrei) is a species of worm lizard in the family Amphisbaenidae. The species is endemic to Brazil.
The specific name, pretrei, is in honor of French artist Jean-Gabriel Prêtre.
A. pretrei is reddish brown dorsally, and white ventrally. It may attain a snout-to-vent length of 28 cm (11 in), with a tail 3.4 cm (1.3 in) long.
A. pretrei is oviparous.