Sepia confusa is a species of cuttlefish native to the southwestern Indian Ocean, specifically southeastern Africa from Port Elizabeth to southern Mozambique,Zanzibar and Pemba (5° to 30ºS), and Madagascar. S. confusa has also been erroneously recorded from the Arabian Sea. A record from the Saya-de-Malha Bank has not been confirmed by recent expeditions. The species lives at a depth of between 53 and 352 m.
Sepia confusa grows to a mantle length of 150 mm.
The type specimen was collected near Tongaat Beach, Port Elizabeth, South Africa. It is deposited at The Natural History Museum in London.
