Loxopholis osvaldoi is a species of lizard in the family Gymnophthalmidae. The species is endemic to Brazil.
The specific name, osvaldoi, is in honor of Brazilian herpetologist Osvaldo Rodrigues da Cunha.
L. osvaldoi is found in the Brazilian states of Amazonas, Mato Grosso, Pará, and Rondônia.
The natural habitat of L. osvaldoi is forest.
L. osvaldoi is oviparous.