Hosmer's spiny-tailed skink is mostly reddish-brown on top, with both scattered darker and paler spots along the back, legs, and tail. It has a darker brown head and neck, white abdomen, and a few dark brown blotches under the chin. The snout–vent length (SVL) is 180mm, with a round, tapering tail about 60% of the SVL. It is most closely related to Cunningham's spiny-tailed skink (Egernia cunninghami ), however the tail of E. hosmeri is flattened and spinier than that of E. cunninghami.
Hosmer's spiny-tailed skin is found throughout dry, rocky regions of Queensland and the Northern Territory.
Hosmer's spiny-tailed skink is omnivorous, eating insects, leaves, shoots, and berries.
Like some other reptiles, it is viviparous, giving birth to an average of four live young at a time.