Pristimantis zophus is a species of frog in the family Craugastoridae. It is endemic to Colombia and is only known from the eastern slopes of the northern Cordillera Central in the Antioquia Department. The specific name is derived from Greek zophus, meaning "darkness" or "gloom". It refers to the drab coloration of this frog, as well as its habit of becoming active after the sunset.
Adult males measure 14–17 mm (0.6–0.7 in) and adult females 16–20 mm (0.6–0.8 in) in snout–vent length. The head is as broad as the body in males but narrower in females. The snout is rounded in females, but in males it is subacuminate in the dorsal view. The tympanum is round. The fingers and the toes have discs and lateral keels but no webbing. Skin is smooth. Coloration of most individuals is in shades of brown with darker markings, but the ground color may also be pale cream-grey. The iris is reticulated with black and either very pale green, or pale brassy color above with red horizontal streak and gray below.
