Cassiopea andromeda is one of many cnidarian species called the upside-down jellyfish. It usually lives in intertidal sand or mudflats, shallow lagoons, and around mangroves. This jellyfish, often mistaken for a sea anemone, usually keeps its mouth facing upward. Its yellow-brown bell, which has white or pale streaks and spots, pulsates to run water through its arms for respiration and to gather food.
This jellyfish can measure a maximum of 30.0 cm wide.
As a cnidarian, this jellyfish has an asexual and sexual reproduction. It reproduces by budding when it is in a polyp form. When it is in a medusa form, it reproduces sexually. The medusa female produces the eggs and keeps them. As the male produces the sperm and releases them in the water, the female uses its tentacles to bring the sperm to fertilize its eggs.