Darlington's least gecko (Sphaerodactylus darlingtoni) is a species of lizard in the family Sphaerodactylidae. The species is endemic to the Dominican Republic.
The specific name, darlingtoni, is in honor of American entomologist Philip Jackson Darlington, Jr., who collected the holotype.
The subspecific name, noblei, is in honor of American herpetologist Gladwyn Kingsley Noble.
The preferred habitat of S. darlingtoni is forest at altitudes of 5–1,300 m (16–4,265 ft).
S. darlingtoni is oviparous.