The Mato Grosso blind snake (Siagonodon cupinensis ) is a species of snake in the family Leptotyphlopidae. The species is native to northeastern South America.
S. cupinensis is uniformly yellowish, not striped. It has on average 270 middorsal scales from rostral to tail tip.
S. cupinensis is found in the Brazilian states of Amapá, Mato Grosso, and Pará, and in Suriname.
The preferred natural habitat of S. cupinensis is savanna.
S. cupinensis is oviparous.