The Sacramento pikeminnow (Ptychocheilus grandis), formerly known as the Sacramento squawfish, is a large cyprinid fish of California, United States. It is native to the Los Angeles River, Sacramento-San Joaquin, Pajaro-Salinas, Russian River, Clear Lake and upper Pit River river basins. It is predatory and reaches up to 1.4 m (4.6 ft) in total length.

The species has been introduced into the Salt River, where it is considered an invasive species.

The species was introduced to the Eel River watershed in the 1970s by anglers using the pikeminnow as bait. It has a large appetite for salmonid species once it reaches about 6 inches (15 cm) long. Until then, it eats anything in its path. Because it is invasive in the Eel River, it has very few predators. River otter populations have increased and helped stabilize the pikeminnow population, but they still put pressure on endangered salmonid species.